Mounjaro

Weight-loss drugs killed my appetite for life

Sam Altman, the co-founder of OpenAI, which launched ChatGPT, is not overweight. Gay tech billionaires rarely are. Even so, as he explained in a recent interview, he was keen to try a GLP-1, one of those drugs that have revolutionised weight loss in the past five years. You can understand why he was curious. Ozempic or Mounjaro might appear to have nothing in common with artificial intelligence, but both phenomena have created a sensation that we’re entering an era of accelerating and uncontrollable change. Alas, he screwed it up. He had someone inject him with a megadose, puked all night and then lay in bed for days ‘staring at a white ceiling thinking nothing’, not only feeling no urge to eat but also no ‘desire for anything’.

Don’t blame Trump for food price hikes and cancelled flights

From our UK edition

In the hierarchy of factors that will make consumers curse politicians and company bosses this summer, food price inflation probably ranks higher than holiday flight chaos. But both will contribute to an ugly mood that will manifest everywhere from Question Time audiences and airport voxpops to outbreaks of mass shoplifting. And only the last blip of both irritants can truly be blamed on what’s happening in the Strait of Hormuz. A thinktank report grabbed headlines on Monday with the claim that UK food prices could be 50 per cent higher by November than they were at the onset of the cost-of-living crisis in 2021. But that’s not a particularly startling figure, given that ONS statistics for the five years to November 2025 already showed a 38.

When did gyms become so unfriendly?

From our UK edition

One of the drawbacks of being on the jabs is that you can lose muscle mass as well as body fat. I’ve been taking Mounjaro for about six months and, apart from the expense, I have few complaints. I’ve lost about 20lb and generally feel healthier. But Caroline insists I combine the weight loss with lifting weights, so I’ve been making regular visits to a gym in White City. I hear horror stories from gym users about people treating the space as if it’s their personal film set I used to be a bit of a gym rat in my twenties and thirties, but marriage and children, not to mention a full workload, put paid to that. Not much has changed in the last quarter century, save for one glaring difference: everyone is constantly on their phones.